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Hereditary transthyretin-mediated (hATTR) amyloidosis can progress quickly and lead to significant burden1-3


Decreased ambulation2

  • Inability to walk unaided
  • Wheelchair-bound or bedridden

Decline in daily function3-5

  • Impairment in self-care
  • Impairment in ability to perform usual activities
  • Pain/discomfort

Social burden6

  • Anxiety
  • Depression

Premature death7

  • hATTR amyloidosis can lead to premature death in 4.7 yearsa

aMedian survival following diagnosis.

hATTR amyloidosis can lead to significant disability and dysfunction.1-3



  1. Ando Y, Coelho T, Berk JL, et al. Orphanet J Rare Dis. 2013;8:31.
  2. Coutinho P, Martins da Silva A, Lopes Lima JL, et al. Excerpta Medica; 1980:88-98.
  3. Vinik EJ, Vinik AI, Paulson JF, et al. J Peripher Nerv Syst. 2014;19:104-119.
  4. Vinik EJ, Hayes RP, Oglesby A, et al. Diabetes Technol Ther. 2005;7(3):497-508.
  5. Pruppers MHJ, Merkies ISJ, Faber CG, et al. J Peripher Nerv Syst. 2015;20(3):319-327.
  6. Lopes A, Fonseca I, Sousa A, et al. Amyloid. 2018;25(1):26-36.
  7. Sweicicki PL, Zhen DB, Mauermann ML, et al. Amyloid. 2015;22(2):123-131.