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Dosing & Preparation

ONPATTRO® (patisiran) is given every 3 weeks1

Step 1: Preparing for ONPATTRO treatment1

  • Patients should be given each of the following premedications on the day of the infusion, at least 60 minutes prior to the start of the infusion:

    —Intravenous (IV) corticosteroid (e.g., dexamethasone 10 mg, or equivalent)

    —Oral acetaminophen (500 mg)

    —IV H1 blocker (e.g., diphenhydramine 50 mg, or equivalent)

    —IV H2 blocker (e.g., ranitidine 50 mg, or equivalent)

  • For premedications not available or not tolerated intravenously, equivalents may be administered orally
  • For patients who are tolerating their ONPATTRO infusions but experiencing adverse reactions from the corticosteroid premedication, the corticosteroid dose may be reduced by 2.5 mg increments to a minimum dose of 5 mg of dexamethasone (IV), or equivalent
  • Some patients may require additional or higher doses of 1 or more of the premedications to reduce the risk of infusion-related reactions

Laboratory monitoring is not required for ONPATTRO.

Step 2: Administering ONPATTRO treatment1

ONPATTRO is administered via an ~80-minute
IV infusion

  • Dosing is based on actual body weight

—For patients weighing <100 kg, the recommended dose is 0.3 mg/kg

—For patients weighing ≥100 kg, the recommended dose is 30 mg

No dose adjustment is required in patients ≥65 years old or with mild hepatic impairment or mild to moderate renal impairment1

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Preparation instructions for ONPATTRO® (patisiran)

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Reference:

  1. ONPATTRO [package insert]. Cambridge, MA: Alnylam Pharmaceuticals, Inc; 2018.