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Dosing guide

Use the table below to calculate the dosage and number of vials needed for patients prescribed ONPATTRO® (patisiran), based on the recommended weight-based dosage1

  • ONPATTRO is supplied as a 10 mg/5 mL solution in a single-dose vial
  • ONPATTRO is administered via IV infusion once every 3 weeks
  • Dosing is based on actual body weight. For patients weighing <100 kg, the recommended dose is 0.3 mg/kg. For patients weighing ≥100 kg, the recommended dose is 30 mg

Proper preparation of ONPATTRO requires filtration to remove particulates. An additional vial of ONPATTRO may be required depending on the type of filter used and the amount of product that remains in the filter (hold-up volume). The dosing table below assumes that 1 mL of drug product remains in the filter when determining the number of vials needed, based on the available manufacturer's information for the PALL PharmAssure®  0.45 micron, 32 mm syringe filter with low protein binding Supor® membrane (Product ID 4614). 

The bold numbers signify weights that may require an additional vial of ONPATTRO due to drug product remaining in the filter.

 

Body
Weight (kg)
mg mL Vials
25 7.5 3.75 1
26 7.8 3.9 1
27 8.1 4.05 2
28 8.4 4.2 2
29 8.7 4.35 2
30 9 4.5 2
31 9.3 4.65 2
32 9.6 4.8 2
33 9.9 4.95 2
34 10.2 5.1 2
35 10.5 5.25 2
36 10.8 5.4 2
37 11.1 5.55 2
38 11.4 5.7 2
39 11.7 5.85 2
40 12 6 2
41 12.3 6.15 2
42 12.6 6.3 2
43 12.9 6.45 2
44 13.2 6.6 2
45 13.5 6.75 2
46 13.8 6.9 2
47 14.1 7.05 2
48 14.4 7.2 2
49 14.7 7.35 2
50 15 7.5 2
51 15.3 7.65 2
52 15.6 7.8 2
53 15.9 7.95 2
54 16.2 8.1 2
55 16.5 8.25 2
56 16.8 8.4 2
57 17.1 8.55 2
58 17.4 8.7 2
59 17.7 8.85 2
60 18 9 2
61 18.3 9.15 3
62 18.6 9.3 3
Body
Weight (kg)
mg mL Vials
63 18.9 9.45 3
64 19.2 9.6 3
65 19.5 9.75 3
66 19.8 9.9 3
67 20.1 10.05 3
68 20.4 10.2 3
69 20.7 10.35 3
70 21 10.5 3
71 21.3 10.65 3
72 21.6 10.8 3
73 21.9 10.95 3
74 22.2 11.1 3
75 22.5 11.25 3
76 22.8 11.4 3
77 23.1 11.55 3
78 23.4 11.7 3
79 23.7 11.85 3
80 24 12 3
81 24.3 12.15 3
82 24.6 12.3 3
83 24.9 12.45 3
84 25.2 12.6 3
85 25.5 12.75 3
86 25.8 12.9 3
87 26.1 13.05 3
88 26.4 13.2 3
89 26.7 13.35 3
90 27 13.5 3
91 27.3 13.65 3
92 27.6 13.8 3
93 27.9 13.95 3
94 28.2 14.1 4
95 28.5 14.25 4
96 28.8 14.4 4
97 29.1 14.55 4
98 29.4 14.7 4
99 29.7 14.85 4
≥100 30 15 4
branch

Reference:

  1. ONPATTRO [package insert]. Cambridge, MA: Alnylam Pharmaceuticals, Inc; 2018.